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St Louis, MO to Chicago, IL Bus Tickets & Schedules

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What to expect of your trip

Fast, easy, and affordable options from St Louis, MO to Chicago, IL

Min. trip duration

6 h 5 min

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Min. distance

511 km

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Cheapest trip

From $58.98

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4

Min. trips a day

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Bus stations and stops in St Louis, MO

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
USB outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
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Onboard services are subject to availability

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Vehicle passing through a city

Digital ticket & live tracking

Discover the FlixBus app

Book trips
Your tickets
Track your trip
Always in the know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

Frequently asked questions

The bus from St Louis to Chicago takes 6 hours 5 minutes.
The bus St Louis to Chicago starts from $58.98. Take advantage of our best deals on bus tickets by traveling off-peak and during the week. You can buy your bus ticket from St Louis to Chicago most easily on this website or in the app.
You can pay for your bus ticket from St Louis to Chicago by card, digital wallet, and other methods. All available payment options for your route are shown at checkout.
Track your bus from St Louis to Chicago in real time using our Bus Tracker on the website or FlixBus app. Just select your stop to check arrival times and any delays on the route.
The earliest bus from St Louis to Chicago departs at 02:00.
The last bus St Louis to Chicago departs at 23:30.
No, you don't need to print your ticket for the bus from St Louis to Chicago. Simply show your ticket on your smartphone or tablet to the driver upon boarding.
Buses from St Louis to Chicago come with free Wi-Fi, power outlets, extra legroom, and onboard toilets. You can also reserve a seat during booking, for the full list, check our onboard services page.
Traveling by bus from St Louis to Chicago is one of the most environmentally-friendly options available as it reduces traffic-associated emissions, and passengers can offset their carbon emissions when they travel with FlixBus by clicking the CO₂ compensation box when booking their ticket.
On the bus from St Louis to Chicago, you can bring one small bag or backpack and two checked bags at no extra cost. Need more? You can add extra luggage when you book for a small fee. For full details, check our luggage policy.
The distance between St Louis and Chicago is approximately 511 km.
Yes, night bus services are available. Taking an overnight bus from St Louis to Chicago allows you to travel while you sleep, saving time and reducing accommodation costs, while arriving at your destination early the next morning. Use this page to check out the route's schedule and read more about overnight and sleeper buses.
Get the best deals on bus tickets to Chicago from St Louis by booking in advance. Travelling on weekdays, choosing off-peak departure times, and being flexible with your travel dates can help you find cheaper fares.
FlixBus departs from 2 stops across St Louis. You can see the exact stop locations and addresses when you book your trip. In Chicago, there are 3 bus stops.
All buses from St Louis to Chicago are wheelchair accessible and equipped with boarding assistance. If you'd like to travel seated in your wheelchair, you can add it during booking at least 24 hours ahead. Your companion person (with a valid Companion Card) and certified service animals travel free of charge. Contact Customer Service at least 24 hours before departure to arrange their booking. For full details, check our accessibility services and companion travel pages.